What Is Cancer of Unknown Primary (CUP)?

Cancer of Unknown Primary (CUP) means cancer has been found in the body, but the place where it started is not yet known. Because of this, each case is unique and requires a personalized approach to care.

How Is It Diagnosed?

Your care team will use a combination of:

• Imaging (CT, PET, MRI, ultrasound)

• Blood tests

• Biopsy

These help better understand the cancer and guide treatment decisions.

Signs and Symptoms

Symptoms vary, but may include:

• Unexplained weight loss

• Fatigue

• Pain or a lump

• Enlarged lymph nodes

• Changes in breathing, bowel, or bladder habits

If you notice any of these, it’s important to talk to your doctor.

Treatment Options

Treatment is personalized and may include:

• Chemotherapy

• Targeted or hormonal therapy

• Radiation

• Surgery (in some cases)

Your care team will work with you to create a plan that fits your needs.

Our Approach at Oncura Health

At Oncura Health, we provide coordinated, patient-centered care—even when answers aren’t immediately clear. Our team works together to guide you through diagnosis, treatment, and beyond with clarity, compassion, and support.